Neurosteroid Synthesis in Adult Female Rat Hippocampus, Including Androgens and Allopregnanolone
نویسندگان
چکیده
منابع مشابه
Unilateral degeneration in hippocampus of female rat
A number of investigations have shown that hippocampal sub regions are particularly vulnerable during stressful conditions [1-5]. Cell loss in hippocampus during normal ageing and also in age-related disorders has also been reported [6]. During the exposure to acute or chronic stress and ischemia, cell loss in hippocampus has been demonstrated [7,8]. Exposure to external stressors like heat can...
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BACKGROUND Hippocampus is an important target for estrogen action. It is severely affected in patients of Alzheimer's disease. Much of the current research related to estrogen and brain function is focused in two directions. PURPOSE By attempting to lacalize localizing ERs in GABAergic neurons of the hippocampus we tried to test the hypothesis that the action of estrogen in maintaining the ne...
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The hypothalamus-pituitary-adrenal (HPA) axis is the major neuroendocrine stress response system. Corticotropin-releasing hormone (CRH) neurons in the parvocellular paraventricular nucleus (pPVN) play a key role in coordinating responses of this system to stressors. The cytokine interleukin-1beta (IL-1beta), mimicking infection, robustly activates these CRH neurons via a noradrenergic input ari...
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Vascular endothelial growth factor (VEGF) is critical to angiogenesis and vascular permeability. It is also important in the endocrine system, in which VEGF mediates the vascular effects of estrogens in target tissues such as the uterus, a response attributed to an estrogen response element on the VEGF gene. Here we asked whether 17β-estradiol increases VEGF levels in the brain. We focused on t...
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Since the first observations on the existence of "neurosteroids" in the 1980s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system (PNS) has increased progressively. Although most of the observations were made in neuronal cells, equally important are the effects that neurosteroids exert on glial cells. Among the different ...
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ژورنال
عنوان ژورنال: Journal of Steroids & Hormonal Science
سال: 2014
ISSN: 2157-7536
DOI: 10.4172/2157-7536.s4-002